小黄书 biologist Gout contributes to study reshaping complexity of aging
Contact: Sarah Nicholas
STARKVILLE, Miss.鈥斝』剖閟ity biologist Jean-Francois Gout鈥檚 contributions to a study highlighting key advances in the complexity of aging now are published in , a leading peer-reviewed journal of the American Association for the Advancement of Science.
Gout鈥檚 collaboration with study lead Marc Vermulst, professor at the University of Southern California, Los Angeles 听Leonard Davis School of Gerontology, and his Ph.D. student Sarah J. Shemtov, focuses on how two major biological systems that influence aging鈥攊nsulin-like growth factor-1, or IGF-1, signaling and mitochondrial function鈥攊nteract to control lifespan in mammals. The open-access Science Advances is widely recognized for publishing high-impact studies across scientific fields.
鈥淭he team鈥檚 work shows that while reducing IGF-1 signaling is widely known to extend lifespan and protect against age-related disease in many organisms, that benefit is not universal,鈥 said Gout, who performed the bioinformatics analysis for this study and provided insight from his 小黄书 work based on molecular evolution.
鈥淲hen the integrity of mitochondrial DNA is compromised, downstream mechanisms that normally promote stress resistance and cellular repair may be blunted, effectively overriding the benefits of IGF-1 reduction. Overall, the study highlights the importance of maintaining the integrity of the mitochondrial genome for many lifespan-extending interventions to work as intended,鈥 he said.
The study, available at , indicates many approaches to extending lifespan depend on keeping the cell鈥檚 energy鈥憄roducing system intact.
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